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Our approach will help close the gap between data-driven and theory-driven models of neural dynamics. We also characterize the space of circuit configurations giving rise to rhythmic activity in the crustacean stomatogastric ganglion, and use these results to derive hypotheses for underlying compensation mechanisms. We demonstrate the power and flexibility of our approach on receptive fields, ion channels, and Hodgkin–Huxley models. Our method is scalable in parameters and data features and can rapidly analyze new data after initial training. We address this challenge with a machine learning tool which uses deep neural density estimators-trained using model simulations-to carry out Bayesian inference and retrieve the full space of parameters compatible with raw data or selected data features. However, determining which model parameters agree with complex and stochastic neural data presents a significant challenge. 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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All preprocessed data supporting the results of this study are available from the Zenodo repository (DOI: 10.5281/zenodo.7876019).įunding: This work was supported by the Fondation Pour l’Audition (FPA RD-2015-2 to LB), the National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering (R01-EB026439 and P41-EB018783 to PB), and the National Institutes of Health's National Institute of Neurological Disorders and Stroke (U24-NS109103, U01-NS108916, and R13-NS118932 to PB R01-NS21135 to RTK). Received: SeptemAccepted: Published: August 15, 2023Ĭopyright: © 2023 Bellier et al. 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